Inicio > Medicina > Otras ramas de la medicina > Farmacología > W poszukiwaniu selektywnych inhibitorów 11β-HSD 1 bez nefrotoksyczności
W poszukiwaniu selektywnych inhibitorów 11β-HSD 1 bez nefrotoksyczności

W poszukiwaniu selektywnych inhibitorów 11β-HSD 1 bez nefrotoksyczności

Harun Patel / Kiran Dhangar / Rakesh Jagtap

68,04 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209551697
68,04 €
IVA incluido
Disponible
Añadir a favoritos
Sobre IBD

Nadekspresja 11β-HSD 1 w kluczowych tkankach metabolicznych jest związana z rozwojem cukrzycy typu 2, otyłości, nadciśnienia i zespołu metabolicznego. Niedawno opisano nefrotoksyczność kwasu korosolowego (selektywnego inhibitora 11β-HSD 1), co stanowi jedną z głównych wad tego związku. Dlatego też bardzo interesujące jest znalezienie selektywnych inhibitorów 11β-HSD 1 bez nefrotoksyczności. Wykorzystując struktury krystaliczne 11β-HSD 1 w kompleksie z inhibitorami jako źródło informacji strukturalnych, zastosowano połączone podejście oparte na wirtualnym przesiewaniu strukturalnym, a następnie prognozowaniu toksyczności PASS, regule Lipinskiego i prognozowaniu ADME w celu znalezienia silnego i selektywnego analogu 11 β-HSD 1 kwasu korosolowego bez nefrotoksyczności.

Artículos relacionados

  • Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential
    Guangshun Wang
    Antimicrobial peptides are key defense molecules adopted by all life forms to prevent infection. They also have other beneficial effects such as boosting immune response, anticancer, and wound healing. The antiviral effects of antimicrobial peptides have laid the foundations for developing new agents to combat seasonal Flu, HIV-1, RSV, Zika, and Ebola. This eBook is constructed...
    Disponible

    67,96 €

  • Mind Maps of Clinical Research Basics
    Amrita Akhouri
    The concepts of Clinical Research have been depicted through mind maps in this book which makes the subject fundamentals very easy to understand and convenient to revise. The chapter on career in clinical research gives an insight into the main job roles currently known in this field along with the focus on how to build preparedness for job interviews. Hence, this book will be ...
    Disponible

    25,42 €

  • Marine Polysaccharides Volume 2
    Paola Laurienzo
    The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailorin...
    Disponible

    75,84 €

  • Marine Polysaccharides Volume 3
    Paola Laurienzo
    The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailorin...
    Disponible

    116,84 €

  • Herbs Used for Hair Growth
    Devi Raman / V. Varalakshmi
    Natural medicine has many benefits, from nourishing the scalp to stimulating hair follicles. Some popular herbs that aid hair growth include rosemary, ginseng, aloe vera, and fenugreek. Each plant has unique properties that help strengthen hair, prevent breakage, and promote growth, healthy growth. Of course, many herbs are popular for their beneficial effects in promoting hair...
    Disponible

    54,32 €

  • Novel Anti-proliferative Agents
    Valentina Onnis
    This Special Issue of Pharmaceuticals presented the recent findings on antiproliferative compounds and highlighted possible routes to discover new drugs used to treat cancer. In this Special Issue, different studies on kinase and methyltransferase-like proteins 3 inhibitors and compounds capable of altering the tumor microenvironment or acting at the mitotic stage of the cell c...
    Disponible

    117,59 €

Otros libros del autor

  • À la recherche d’inhibiteurs sélectifs de la 11β-HSD 1 sans néphrotoxicité
    Harun Patel / Kiran Dhangar / Rakesh Jagtap
    La surexpression de la 11β-HSD 1 dans les tissus métaboliques clés est liée au développement du diabète de type 2, de l’obésité, de l’hypertension et du syndrome métabolique. La néphrotoxicité de l’acide corosolique (inhibiteur sélectif de la 11β-HSD 1) a récemment été rapportée, ce qui constitue l’un des principaux inconvénients. Il est donc très intéressant de trouver des inh...
    Disponible

    66,79 €

  • Alla ricerca di inibitori selettivi dell’11β-HSD 1 senza nefrotossicità
    Harun Patel / Kiran Dhangar / Rakesh Jagtap
    La sovraespressione dell’11β-HSD 1 nei tessuti metabolici chiave è correlata allo sviluppo del diabete di tipo 2, dell’obesità, dell’ipertensione e della sindrome metabolica. Recentemente è stata segnalata la nefrotossicità dell’acido corosolico (inibitore selettivo dell’11β-HSD 1), che rappresenta uno dei principali svantaggi. Pertanto, è di grande interesse individuare inibit...
    Disponible

    68,04 €

  • Em busca de inibidores seletivos da 11β-HSD 1 sem nefrotoxicidade
    Harun Patel / Kiran Dhangar / Rakesh Jagtap
    A superexpressão da 11β-HSD 1 em tecidos metabólicos essenciais está relacionada com o desenvolvimento de diabetes tipo 2, obesidade, hipertensão e síndrome metabólica. Recentemente, foi relatada a nefrotoxicidade do ácido corosólico (inibidor seletivo da 11β-HSD 1), o que constitui uma das principais desvantagens. Portanto, é de grande interesse descobrir inibidores seletivos ...
    Disponible

    68,04 €

  • Auf der Suche nach selektiven 11β-HSD 1-Inhibitoren ohne Nephrotoxizität
    Harun Patel / Kiran Dhangar / Rakesh Jagtap
    Die Überexpression von 11β-HSD 1 in wichtigen Stoffwechselgeweben steht im Zusammenhang mit der Entwicklung von Typ-2-Diabetes, Adipositas, Bluthochdruck und metabolischem Syndrom. Kürzlich wurde über die Nephrotoxizität von Corosolsäure (selektiver Inhibitor von 11β-HSD 1) berichtet, was einen der größten Nachteile darstellt. Daher ist es von großem Interesse, selektive 11β-HS...
    Disponible

    68,10 €