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Auf der Suche nach selektiven 11β-HSD 1-Inhibitoren ohne Nephrotoxizität

Auf der Suche nach selektiven 11β-HSD 1-Inhibitoren ohne Nephrotoxizität

Harun Patel / Kiran Dhangar / Rakesh Jagtap

68,10 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209554254
68,10 €
IVA incluido
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Die Überexpression von 11β-HSD 1 in wichtigen Stoffwechselgeweben steht im Zusammenhang mit der Entwicklung von Typ-2-Diabetes, Adipositas, Bluthochdruck und metabolischem Syndrom. Kürzlich wurde über die Nephrotoxizität von Corosolsäure (selektiver Inhibitor von 11β-HSD 1) berichtet, was einen der größten Nachteile darstellt. Daher ist es von großem Interesse, selektive 11β-HSD 1-Inhibitoren ohne Nephrotoxizität zu finden. Unter Verwendung der Kristallstrukturen von 11β-HSD 1 im Komplex mit Inhibitoren als Quelle für Strukturinformationen wurde ein kombinierter strukturbasierter virtueller Screening-Ansatz gefolgt von einer PASS-Toxizitätsvorhersage, der Lipinski-Regel und einer ADME-Vorhersage implementiert, um ein wirksames und selektives 11β-HSD 1-Analogon von Corosolsäure ohne Nephrotoxizität zu finden.

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Otros libros del autor

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