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Em busca de inibidores seletivos da 11β-HSD 1 sem nefrotoxicidade

Em busca de inibidores seletivos da 11β-HSD 1 sem nefrotoxicidade

Harun Patel / Kiran Dhangar / Rakesh Jagtap

68,04 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209549137
68,04 €
IVA incluido
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A superexpressão da 11β-HSD 1 em tecidos metabólicos essenciais está relacionada com o desenvolvimento de diabetes tipo 2, obesidade, hipertensão e síndrome metabólica. Recentemente, foi relatada a nefrotoxicidade do ácido corosólico (inibidor seletivo da 11β-HSD 1), o que constitui uma das principais desvantagens. Portanto, é de grande interesse descobrir inibidores seletivos da 11β-HSD 1 sem nefrotoxicidade. Utilizando estruturas cristalinas da 11β-HSD 1 em complexo com inibidores como fonte de informação estrutural, foi implementada uma abordagem combinada de triagem virtual baseada em estrutura, seguida pela previsão de toxicidade PASS, regra de Lipinski e previsão ADME, para descobrir o análogo potente e seletivo da 11 β-HSD 1 do ácido corosólico sem nefrotoxicidade.

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Otros libros del autor

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