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Sviluppo della formulazione di microparticelle di rifaximina a rilascio prolungato

Sviluppo della formulazione di microparticelle di rifaximina a rilascio prolungato

Kiran Bhise / Rohan Karanje

49,19 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209324987
49,19 €
IVA incluido
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Questo libro tratta gli aspetti relativi alla formulazione e alla progettazione del processo delle microparticelle a rilascio prolungato del farmaco Rifaximin di classe IV BCS attraverso la complessazione con ciclodestrina e il prolungamento del rilascio del farmaco mediante rivestimento enterico Eudragit L -100. Il concetto di metodologia di risposta superficiale è stato utilizzato nella selezione del lotto ottimizzato, che è stato ulteriormente valutato per vari parametri. I dati supportano un miglioramento della solubilità in acqua dei farmaci di classe IV BCS attraverso complessi di ciclodestrina. Il rilascio di tali complessi di inclusione può essere ritardato di 8 ore grazie al rivestimento enterico.

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