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Opracowanie receptury mikrocząstek rifaksyminy o przedłużonym uwalnianiu

Opracowanie receptury mikrocząstek rifaksyminy o przedłużonym uwalnianiu

Kiran Bhise / Rohan Karanje

49,19 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209327544
49,19 €
IVA incluido
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Książka ta dotyczy formułowania i projektowania procesu wytwarzania mikrocząstek o przedłużonym uwalnianiu leku Rifaximin klasy IV BCS poprzez kompleksowanie cyklodekstryną i przedłużanie uwalniania leku poprzez powlekanie powłoką dojelitową Eudragit L -100. Przy wyborze zoptymalizowanej partii zastosowano metodologię odpowiedzi powierzchniowej, która została następnie poddana dalszej ocenie pod kątem różnych parametrów. Dane potwierdzają poprawę rozpuszczalności w wodzie leków klasy IV BCS poprzez kompleksy cyklodekstryny. Uwalnianie takich kompleksów inkluzyjnych można opóźnić o 8 godzin poprzez zastosowanie powłoki dojelitowej.

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