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Badanie zachowania chromatograficznego alkaloidów maku lekarskiego

Badanie zachowania chromatograficznego alkaloidów maku lekarskiego

Aneta Dimitrovska / Gjoshe Stefkov / Jelena Acevska

93,68 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209516399
93,68 €
IVA incluido
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Nadmierne i stale rosnące zainteresowanie jednoczesnym oznaczaniem alkaloidów maku lekarskiego wymaga opracowania i optymalizacji wygodnych metod wysokoprzepustowych do oceny profilu jakościowego i ilościowego alkaloidów w słomie makowej. Systematyczna optymalizacja kilku metod chromatograficznych (GC/FID/MS, RP-HPLC/DAD, Si-HILIC/DAD i ZIC-HILIC/DAD) do rozdzielania głównych alkaloidów (morfina, kodeina, tebaina, oripawina, papaweryna i noskapina) obecnych w słomie maku lekarskiego (Papaver somniferum L., Papaveraceae) przeprowadzono przy użyciu metody projektowania eksperymentów. Dzięki racjonalnej optymalizacji metod uniknięto wielu zbędnych i nieproduktywnych badań laboratoryjnych. Opracowane metody zostały zweryfikowane i porównane pod kątem rozdzielczości, czułości, dokładności, szybkości, kosztów, aspektów ekologicznych i zgodności z procedurą ekstrakcji słomy makowej. Proponowane metody zapewniają zarówno szybkie badanie przesiewowe, jak i dokładną ocenę zawartości alkaloidów w próbkach maku uzyskanych w ramach programu selekcji odmian maku.

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