This book discusses the novel frontiers in the processes of vasculogenesis and angiogenesis. Vasculogenesis is the process of formation of new blood vessels when embryonic development of the cardiovascular system takes place. Formation of a vascular tree and finally, the cardiovascular system, with a mesh of blood vessels - that has a role in the nourishment of all tissues and organs - follows this process. Angiogenesis is the process involving evolution of new blood vessels from existing blood vessels by 'sprouting' of endothelial cells, thereby expanding the vascular tree. Both of these processes are based on activation, migration, proliferation and maturation of unique precursor cells. The study of blood vessel development is of paramount significance in the biomedical field due to its crucial role in congenital malformations, embryonic growth, inflammation, degenerative illnesses and cancer. Furthermore, scientists are now considering formation of living blood vessel substitutes for replacement of diseased arteries and veins by implementing this knowledge. This book highlights latest advances in the field of vasculogenesis and angiogenesis, including embryogenesis and development, regulation of progenitor cells, cancer and blood vessel regeneration. It will prove to be an invaluable reference for graduate students, medical students and scientists who are enthusiastic in knowing about the complexities of blood vessel formation, maturation, disease and replacement. 3
