This two-set volume CCIS 3103-3104 constitutes the proceedings of the 17th International Conference on Management of Digital EcoSystems, MEDES 2025, held in Ho Chi Minh City, Vietnam, during November 24-26, 2025. The 46 full papers and 12 short papers included in these volumes were carefully reviewed and selected from 96 submissions. They are organized into topical sections as follows: Part I: Education and Learning; Deep Learning; Smart Cities; Parallel and Distributed Architectures; Modeling and Ontologies; AI Theoretical Issues; Health and Medical Issues; Theoretical Issues; AI Technical Issues; and Applications. Part II: Workshop: AI-SBKE,Workshop: DEPRWorld,Workshop: AI-Driven MultiGIS and Student Track.